It is postulated by some of the best known Geologists in the State of Alaska that the age of the GOLD intrusives in the Ophir-Iditarod Mining District are Late Cretaceous - Early Tertiary (LK-ET). This places the time around the extinction of the Dinosaurs, about 65 Million years ago. Most of the Intrusive Related Gold (IRG) Deposits are related to the formation of the Iditarod - Nixon Fork (INF) Fault Zone.
Remote Prospecting in Alaska is like prospecting on the Moon;

The ground is completely covered with alluvium. Alluvium is a variable layer of sand and gravel covered by a variable layer of dense mud. The alluvium is covered by a layer of Tundra.
Early prospectors followed navigable rivers and trails like the Innoko River and Iditarod Trail to reach tributaries in their search for GOLD. Those "Easy" places where GOLD could be panned and taken to the bank have been discovered and mined to the maximum extent possible. The GOLD that remains is covered by sediments that are deep and in the early part of the season, frozen.
Prospecting in these places require extraordinary planning. You practically need a space ship to get there and you have to pack everything you need to survive and prospect in a little spaceship!

- Geowizard